The Biology of AIDS: Course Syllabus

Course

BSC 4933, University of South Florida The Biology of AIDS

Term

Spring - 1994

Instructor

D. D. Dunigan

Class Time and Place

Tuesday/Thursday, 3:30 - 4:45 pm, LIF 272

Instructor's Office

BSF 133

Office Hours

Tuesday, 5 - 6 pm/Thursday, 1 - 3 pm

Required Materials

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs, USF Bookstore
Dunigan, DD (1994) The Biology of AIDS, Pro-Copy Application for Public Health Service Grant, Pro-Copy

Objectives

The purpose of this course is to introduce students to the fundamental problems associated with the biology of AIDS. These problems include: 1) understanding the nature and transmission patterns of the etiological agent(s); 2) understanding associated opportunistic infections and cancers; 3) understanding how to measure the disease and the associated treatments; 4) understanding current strategies for treatment, the associated problems and the prospects for new treatments; and 5) understanding methods of prevention. This course is not designed to address the the sociological, economical or legal aspects of AIDS; however, selected topics in these areas will be addressed by regional experts.

The course format will include lectures and student-initiated discussions based on the assigned reading materials. The lectures will be enhanced by the participation of regional experts in the fields of microbiology, immunology, epidemiology and clinical therapy. Students will be expected to be active learners.

Grading

The final grade will be based, in part, on assigned writing projects, one major term paper and a term journal. The "term journal" will consist of personal responses to the assigned readings and lectures for the preceding week, and will consist of approximately 250 words per week maintained in a two-hole tab binder. The "major term paper" will simulate a grant proposal using the National Institutes of Health format. These proposals will be student-initiated and researched. Additional writing assignments will include critiques of fellow students' proposals.

Assignment                              Points
Localization of AIDS-related materials    5
Critique #1                              10/5
Critique #2                              10/5
Proposal                                 40
Journal                                  25
Bonus                                    10

Syllabus, The Biology of AIDS

1/6/94, USF-Tampa

Jan. 6

Course Logistics

Dynamics of HIV Disease/AIDS

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Introduction, xxi-xxxii)

Jan. 12

Overview of the Pathogenesis of HIV: What Are the Major Questions?

Reading:

Jasny, BR (1993) Editorial (AIDS 1993: Unanswered questions), Science 260: 1219
Cohen, J (1993) Special News Report Science 260: 1254-1265
Cohen, J (1993) Somber news from the AIDS front, Science 260: 1712-1713

Jan. 14

Team Assignments

Reading:

Introduction to Retrovirus Biology and Replication Gallo, RC (1986) The first human retrovirus, Scientific American 255(6): 88-98
Varmus, H (1987) Reverse transcription, Scientific American 257(3): 56-64

Jan. 19

Introduction to the Immune System

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 1, 1-29)
Nossal, GJV (1993) Life, death and the immune system, Scientific American 269(3): 52-62
Weissman, IL and Cooper, MD (1993) How the immune system develops, Scientific American 269(3): 65-71
Janeway, CA (1993) How the immune system recognizes invaders, Scientific American 269(3): 73-79

Jan. 21

Discussion Session: Selecting Proposal Topics; Team Functions; Writing a Grant Proposal

Reading:

Application for Public Health Service Grant

Jan. 25

Introduction to Retroviruses

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 2, 32-66)
Gallo, RC (1987) The AIDS virus, Scientific American 256(1): 46-56

Jan. 27

Human Immunodeficiency Virus: Replication and Regulation of HIV Expression

Reading:

Wong-Staal, F (1991) Human immunodefiency viruses and their replication, Fundamental Virology, 2nd Edition, Ed. B.N. Fields and D.M. Knipe, Raven Press, Ltd., New York, 709-723.

Feb. 1

Evolution of HIV

Reading:

Essex, M and Kanki, PJ (1988) The origins of the AIDS virus, Scientific American 259(4): 64-71
Delwart, EL et al. (1993) Genetic relationships determined by a DNA heteroduplex mwility assay: Analysis of HIV-env genes, Science 262: 1257-1261
Eigen, M (1993) Viral quasispecies, Scientific American 269(1): 42-49

Feb. 3

HIV Replication: Additive or Synergistic Effects of Co-factors

Reading:

Greene, WC (1993) AIDS and the immune system, Scientific American 269(3): 99-105

Feb. 8

Introduction to the Epidemiology of HIV/AIDS

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 6, 156-194)

Feb. 10

Discussion Session: Proposal Reviews

Feb. 15

DEADLINE: Proposal 1st Draft

HIV Transmission; Testing for HIV

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 7, 195-226)
Mullis, KB (1990) The unusual origin of the polymerase chain reaction, Scientific American 262(4): 56-65
Patterson, BK et al. (1993) Detection of HIV-1 and messenger RNA in individual cells by PCR-driven in situ hybridization and flow cytometry, Science 260: 976-979
Merson, MH (1993) Slowing the spread of HIV: Agenda for the 1990s, Science 260: 1266-1268

Feb. 17

HIV Transmission: The Dental Perspective

Reading:

Gruninger, SE et al. (1992) Human immunodeficiency virus type 1 infection among dentists, Journal of the American Dental Association 123: 57-64

Feb. 22

DEADLINE: Team Review Critique Due

Prevalence of HIV Infection Inside and Outside of the United States

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapters 8 & 9, 227-282)
Anderson, RM and May, RM (1992) Understanding the AIDS pandemic, Scientific American 266(5): 58-66

Feb. 24

Prevention of HIV Infection

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 7, 195-226)

Mar. 1

Materials for Prevention of HIV Infection

Mar. 3

Discussion Session: Pathogenesis

Reading:

Fauci, AS (1993) Multifactorial nature of human immunodefiency virus disease: Implications for therapy, Science 262: 1011-1018
Gougeon, M-L and Montagnier, L (1993) Apoptosis in AIDS, Science 260" 1269-1270
Weiss RA (1993) How does HIV cause AIDS? Science 260: 1273-1279

Mar. 8

DEADLINE: Proposal 2nd Draft

Introduction to Vaccine Development

Reading:

Lerner, RA (1983) Synthetic vaccines, Scientific American 248(2): 66-74

Mar. 10

HIV Prophylactic Vaccine Development

Reading:

Matthews, TJ and Bolognesi, DP (1988) AIDS vaccines, Scientific American 259(4): 120-127
Salk, J et al. (1993) A strategy for prophylactic vaccination against HIV, Science 260: 1270-1272
Haynes, BF (1993) Scientific and social issues of human immunodeficiency virus vaccine development, Science 260: 1279-1286

Mar. 22

Opportunistic Infections and Cancers Associated with HIV Infection

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 3, 67-91)

Mar. 24

DEADLINE: Experts Review Critique

Clinical Indicators of HIV Infection and AIDS

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 4, 92-115)

Mar. 29

Introduction to AIDS Dementia

Mar. 31

Discussion Session: HIV Infection/AIDS the Clinical Picture

Reading:

???? Concorde studies???

Apr. 5

Therapy for HIV Infection and Opportunistic Infections: Biochemical Basis

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 5, 116-155)
Cohen, J (1993) T cell shift: Key to AIDS therapy? Science 262: 175-176

Apr. 7

Therapy for HIV Infection and Opportunistic Infections: Clinical Picture

Reading:

Johnston, MI and Hoth, DF (1993) Present status and future prospects for HIV therapies, Science 260: 1286-1293

Apr. 12

Pediatric HIV Disease: Vertical Transmission

Apr. 14

Pediatric AIDS: Clinical Drug Trials

Apr. 19

HIV Infection/AIDS: The Legal Dimension

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapter 14, 392-430)

Apr. 21

DEADLINE: Proposal Final Draft

HIV Infection/AIDS: The Social Dimension

Reading:

Stine, GJ (1993) Acquired Immune Deficiency Syndrome: Biological, Medical, Social and Legal Issues, Prentice-Hall, Englewood Cliffs (Chapters 12 & 13, 345-391)

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Last Modified October 13, 1994